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The Journal of the Royal Society for the Promotion of Health
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An overview of biochemical markers in acute coronary syndromes

A. Olukoga

9 Jayton Avenue, East Didsbury, Manchester M20 5QD, England

D. Donaldson

East Surrey Hospital, Redhill, Surrey and Crawley Hospital, Crawley, West Sussex, England

The cardiac troponins (cTns), cTnT and cTnI, are currently regarded as being the most useful diagnostic and prognostic biochemical mark ers of myocardial damage in patients with sus pected acute coronary syndromes (ACSs). In spite of the evidence-based nature of this observation, the uptake of serum cTn mea surement in routine clinical practice - in both the UK and elsewhere, is patchy; indeed, there still exists wide variability in the range of test ing and sampling strategies involving usage of the many existing cardiac markers. For evaluat ing suspected acute myocardial infarction (AMI) and other ACSs, international opinion favours either serum cTnT or cTnI (measured 12-24 h after admission to the emergency room) - together with a short-time window marker such as serum creatine kinase (CK) (measured on admission and perhaps again within the 12-24 h window). Translation of this strategy into universal clinical practice would require not only formulation of, but also strict adherence to, agreed clinical decision- making protocols which, in turn, would need to be backed by adequate funding.

Key Words: Acute coronary syndromes (ACSs) • biochemical markers • cardiac troponins (cTns) • creatine kinase (CK); overview

The Journal of the Royal Society for the Promotion of Health, Vol. 121, No. 2, 102-106 (2001)
DOI: 10.1177/146642400112100211
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