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The Journal of the Royal Society for the Promotion of Health
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Overactive bladder

Rajesh Kavia, MRCS

Department of Urology, Chase Farm Hospital, The Ridgeway, Enfield EN2 8JL, England

Faiz Mumtaz, MD, FRCS(Urol)

Department of Urology, Chase Farm Hospital, The Ridgeway, Enfield EN2 8JL, England; Tel: +44 (0)20 8366 6600 ext 5916 faizmumtaz12{at}aol.com

Overactive bladder (OAB) is defined as urgency, with or without urge incontinence, usually with frequency and nocturia, in the absence of local pathological or hormonal factors. It is a common complaint of men and women alike, with estimates of 22 million sufferers. Approximately 70% of men with bladder outflow obstruction will have some symptoms of OAB. The exact pathophysiology of OAB in bladder outflow obstruction is yet to be elucidated; evidence to date points to changes in both the efferent and afferent innervation and the detrusor. Management of OAB can be is generally with pharmacological agents such as anticholinergics or operative measures such as the ëClamí cystoplasty. More recent treatment modalities include intravesical oxybutynin, intradetrusor botulinum toxin and neuromodulation. More specific treatment options for OAB in bladder outflow obstruction include relief of the obstruction with surgical (e.g. transurethral resection of prostate) or pharmaceutical (e.g. a blockers) methods.

Key Words: Anticholinergics • bladder outflow obstruction • detrusor overactivity • lower urinary tract symptoms • prostatectomy

The Journal of the Royal Society for the Promotion of Health, Vol. 125, No. 4, 176-180 (2005)
DOI: 10.1177/146642400512500411
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